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256 Understanding the molecular mechanisms underlying the adaptation of the ACL to mechanical stress can inform the development of personalized training and rehabilitation programs that optimize the mechanical loading conditions to enhance ligament strength and reduce the risk of injury

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For example, it may be: Pulled off its attachment at the base of the first bone (the proximal phalanx) in the thumb Pulled off the metacarpal bone, where it originates Torn through its middle, though this is less common Cause Any strong force that bends the thumb backward and away from the palm of the hand can stretch or tear the ulnar collateral ligament